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SAM-e Supplement

SAM-e (S-Adenosyl methionine) is an amino acid derivative needed by the body for at least 40 biochemical reactions. It has a reputation as one the most effective natural anti-depressants, supporting a positive outlook without any of the unpleasant side effects of prescription drugs.

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  • Doctor's Best
    30 tablets

    RRP: NZ$69.90

    Save 23% (NZ$16.00)

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  • Doctor's Best
    60 tablets

    RRP: NZ$69.90

    Save 23% (NZ$16.00)

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    RRP: NZ$79.95

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    30 tablets

    RRP: NZ$78.80

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SAM-e Info

SAM-e (S-Adenosyl methionine) is an amino acid derivative needed by the body for at least 40 biochemical reactions. It has a reputation as the most effective natural anti-depressant, without any of the unpleasant side effects of prescription drugs. It was first discovered in 1952 in Italy, and naturally occurs throughout the body when you are in good health. Aging processes, nutrient deficiency, sickness and depression can deplete SAM-e levels, indicating a need for supplementation.

SAM-e Benefits

SAM-e is involved in the manufacture of hormones, cell membranes and mood regulating neurotransmitters. It is a potent mood elevator, energy enhancer, promoter of cell regeneration, neuromuscular balancer and joint mobiliser. It helps maintain cartilage and may support prevention and repair of liver damage.

Studies show SAM-e may be effective in treating depression, fibromyalgia, joint pain, osteoarthritis, liver dysfunction and migraines.

SAM-e is best taken alongside a vitamin B complex to maximise efficacy and prevent side effects.

SAM-e Side Effects

Contraindicated when taking MAOI antidepressant medications. Contraindicated in cases of bipolar disorder unless under close medical supervision as it may promote the manic phase. Contraindicated in Parkinson’s disease as it may aggravate some symptoms. Possible side effects include gastrointestinal upsets: nausea, vomiting, diarrhoea, indigestion. Anxiety, headache, insomnia and allergies may also be experienced.

Product Reviews

  • A little bit expensive, but worth it?

    star- web-tec.info

    Purchased this for fibromyalgia. I have a lot more energy, but it's really hard to tell if its from this product, vitamin B12, or iron which I recently started too. It tastes like delicious sour lollies, which I love! Adds a bit of zing to the day :D



  • Very pleased with this product

    star- web-tec.info

    Fantastic product for joint pain and aching muscles



  • Wonderful

    star- web-tec.info

    Both my wife and I use Sam-e, Donna on a regular basis for OA in her knees and myself after heavy exercise sessions or feeling very anxious. Donna has basically stopped taking pain killers (from the day she started using Sam-e), my after exercise pains and aches are nonexistent at least by the next day and the edge is almost immediately taken of my anxiety so Sam-e really works for both of us and as my Doctor says if you find something that works for you go for it.



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